The list of cosmetic products below is a selection of the most requested cosmetics that contain the ingredient 4 hydroxybenzoic acid. Consequently, some 4hydroxybenzoic acid will be formed then. Theoretical and experimental vibrational spectrum study of 4. However, these chemicals can potentially be degraded by broad spectrum. Molecules are therefore readily easily separated from each other when it is heated. Alkyl esters of 4hydroxybenzoic acid see below are used as food and cosmetic preservatives, mainly in their na salt form, which makes them more water soluble. It can also be produced in the laboratory by heating. An automated spectrophotometric method based on an hplc system with a diode array detector was used to determine the pk a values of compounds with low water solubility in a universal. Showing metabocard for 4hydroxybenzoic acid hmdb0000500. May 25, 2011 salicylic acid 2 hydroxybenzoic acid contains intramolecular hydrogen bonding possible because the groups are next to each other. Where the neat test chemical is weighed and diluted, wear a nioshapproved half face respirator equipped with an organic vaporacid gas cartridge specific for organic. It contains both hydroxyl and carboxyl group at paraposition, which react with either acid or alcohol. Why does 4hydroxybenzoic acid have a higher melting point.
Tabebuia impetiginosa, red sandalwood pterocarpus santalinus, southern catalpa catalpa. It is used as an intermediate in the synthesis of pla sticisers. View detailed import data, price, monthly trends, major importing countries, major ports of 4 hydroxybenzoic acid. Acetylation of 4hydroxybenzoic acid with acetic anhydride. Salicylic acid 2hydroxybenzoic acid contains intramolecular hydrogen bonding possible because the groups are next to each other. Nist chemistry webbook the national institute of standards and technology nist uses its best efforts to deliver a high quality copy of the database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. Liquid crystalline polymers lcp are a relatively unique class of partially crystalline aromatic polyesters based on 4hydroxybenzoic acid and related monomers shown in fig. Tlc analysis of 4hydroxybenzoic acid and 4hydroxybenzoic. A monohydroxybenzoic acid that is benzoic acid substituted by a hydroxy group at position 3. Effect of eluent stabilizer on resolution conditions sample. The oh in salicylic acid the orthoderivative will stabilize the anion due to hydrogen bonding.
What is the shelf life of product 240141, 4 hydroxybenzoic acid. Theoretical and experimental vibrational spectrum study of 4hydroxybenzoic acid as monomer and dimer. The hplc analysis of ethyl acetate, methanol and acetone extracts have given the. It is mostly known as the basis for the preparation of its esters which are parabens. Jcprc5 385 synthesis of 4hydroxybenzoic acid incorporated azo dyes derivatives as potent biological activity molecules ramesh f. Hydroxybenzoic acid derivatives are compounds containing a hydroxybenzoic acid or a derivative, which is a benzene ring bearing a carboxyl and a hydroxyl groups. Structure, properties, spectra, suppliers and links for. The destructive metabolic property of oxygen containing benzoic acid derivatives such as protocatechuic acid 3, 4 dihydroxybenzoic acid and veratric acid 3, 4 dimethoxybenzoic acid is used in the application for pharmaceuticals. The aim of this work was preparation of 1o 4 hydroxybenzoylglycerol, more hydrophilic and naturally occurring analogue of parabens, and comparison of its antimicrobial activity with commercially used parabens 4 hydroxybenzoic acid, methylparaben, ethylparaben, propylparaben. Organism test type route reported dose normalized dose effect source. Alkyl esters of 4 hydroxybenzoic acid see below are used as food and cosmetic preservatives, mainly in their na salt form, which makes them more water soluble. This is used in ophthalmic solutions and as a pres. Acetylation of 4hydroxybenzoic acid with acetic anhydride aa.
Tlc analysis of 4hydroxybenzoic acid and 4hydroxybenzoic acid esters on hptlc silica gel 60 rp18 f254s. Administrative data link to relevant study records description of key information. Nov 17, 2012 because of the proximity of the hydroxyl group and the carboxylic group in this molecule, theres an intramolecular hydrogen bond formed there, whereas in 4 hydroxybenzoic acid this cannot happen, and the hydrogen bond is formed between molecules, thus it has a higher melting point theres more energy needed to break these interactions between. Showing dietary polyphenol 4hydroxybenzoic acid phenol. The destructive metabolic property of oxygen containing benzoic acid derivatives such as protocatechuic acid 3,4dihydroxybenzoic acid. This colorless crystalline organic acid is widely used in organic synthesis and functions as a plant hormone. Biodegradation of 4hydroxybenzoic acid by phomopsis liquidambari. Top, uv visible spectrum, references data from nist standard reference database 69. Pdf metabolism of parabens 4hydroxybenzoic acid esters. This information can be found on the product specification sheet for a related product h20059.
This is used in ophthalmic solutions and as a preservative in certain cosmetics. Antimicrobial effect of 4hydroxybenzoic acid ester with. It a white crystalline solid that is slightly soluble in water and chloroform, but well soluble in alcohols, ether, and acetone. Phytochemical, pharmacological importance of patchouli. Because of the proximity of the hydroxyl group and the carboxylic group in this molecule, theres an intramolecular hydrogen bond formed there, whereas in 4hydroxybenzoic acid this cannot. Easily soluble in hot water, alcohol, ether, and acetone, slightly soluble in cold water and benzene, insoluble in. Showing details for content value of 4hydroxybenzoic acid in. Aspirin ep impurity a, 4hydroxybenzoic acid, aspirin ep impurity b, 4hydroxyisophthalic acid, aspirin ep impurity c, salicylic acid, aspirin ep impurity d, acetylsalicylsalicylic acid, aspirin ep impurity e, 22hydroxybenzoyloxybenzoic acid salicylsalicylic acid, aspirin. The aim of this work was preparation of 1o4hydroxybenzoylglycerol, more hydrophilic and naturally occurring analogue of parabens, and comparison of its antimicrobial activity with commercially used. Consequently, some 4 hydroxybenzoic acid will be formed then.
According to the merck index, 4hydroxybenzoic acid is freely soluble in alcohol, and soluble in about 125 parts water. Oct 01, 2010 glucuronidation of 4 hydroxybenzoic acid and parabens by human liver microsomes and recombinant human ugt the compounds 1 mm were incubated in 100 mm trishcl and 10 mm mgcl 2 ph 7. Theoretical and experimental vibrational spectrum study of 4hydroxybenzoic acid. The second crop of crude acid is filtered with suction and combined with the main portion. Vanillic acid and 4hydroxy3methoxyphenylacetic acid result from the methylation of protocatechuic acid and 3,4dihydroxyphenylacetic acid, respectively. Propyl 4hydroxybenzoate, for biochemical research, also known as propylparaben, is the npropyl ester of phydroxybenzoic acid found in some insects and plants, and manufactured for use in the pharmaceutical, cosmetic and food industrie. I first convert it to the diazo salt using sodium nitrite and sulfuric acid, then i. The list of cosmetic products below is a selection of the most requested cosmetics that contain the ingredient 4hydroxybenzoic acid. Glucuronidation of 4hydroxybenzoic acid and parabens by human liver microsomes and recombinant human ugt the compounds 1 mm were incubated in 100 mm trishcl and 10 mm. It can also be produced in the laboratory by heating potassium salicylate with potassium carbonate to 240 c, followed by treating with acid. Biodegradation of 4hydroxybenzoic acid by phomopsis. Showing details for content value of 4hydroxybenzoic acid in olive, oil, extra virgin food composition.
Protocatechuic acid pca is a dihydroxybenzoic acid, a type of phenolic acid. I make 4hydroxybenzoic acid, and isomer of salicylic acid, from 4aminobenzoic acid, better known as paba. The total weight of crude p hydroxybenzoic acid, m. Please login to display the rating of all cosmetics. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols and acetone. Six aromatic compounds, asebogenin 1, 2,6dihydroxy4methoxydihydrochalcone 2, 3geranyl4methoxybenzoic acid 3, 3geranyl4hydroxybenzoic acid. In the series of hydroxybenzoic acids the order is. Import data and price of 4 hydroxybenzoic acid zauba. This is a classic example of stabilization by hydrogen bonding. The tested cinnamic acids and phydroxybenzoic acid increased pod activity by. Autotoxicity in pogostemon cablin and their allelochemicals. Aspirin ep impurity a, 4hydroxybenzoic acid, aspirin ep impurity b, 4hydroxyisophthalic acid, aspirin ep impurity c, salicylic acid, aspirin ep impurity d, acetylsalicylsalicylic acid, aspirin ep impurity e, 22hydroxybenzoyloxybenzoic acid salicylsalicylic acid, aspirin ep impurity f, acetylsalicylic anhydride.
They are active at low concentrations and more phindependent than the commonly used benzoic acid dvn38z and 2, 4 hexadienoic acid gmz10p. Feb 05, 2018 i make 4 hydroxybenzoic acid, and isomer of salicylic acid, from 4 aminobenzoic acid, better known as paba. According to the merck index, 4 hydroxybenzoic acid is freely soluble in alcohol, and soluble in about 125 parts water. Where the neat test chemical is weighed and diluted, wear a nioshapproved half face respirator equipped with an organic vapor acid gas cartridge specific for organic vapors, hcl, acid gas and so2 with a dustmist filter. Als environmental does not sell chemicals, but offers analytical lab testing to determine the presence of various elements and chemical compounds. Interactions between caffeine and paminobenzoic acid, mhydroxybenzoic acid, picric acid, ophthalic acid, suberic acid, and valeric acid. What is the shelf life of product 240141, 4hydroxybenzoic acid.
However, these chemicals can potentially be degraded by broad spectrum endophytic fungi such as, phomopsis liquidambari strain b3, which is capable of growing on phenolic 4hydroxybenzoic acid 4hba as the sole carbon and energy source. Phenolic acid allelochemicals released by decomposing foliage can have negative impacts on growth of plants and microbes in soil. Salicylic acid from latin salix, willow tree is a lipophilic monohydroxybenzoic acid, a type of phenolic acid, and a beta hydroxy acid bha. Liquid crystal polymers are capable of forming regions of highly ordered structure while in the liquid phase. It is a major metabolite of antioxidant polyphenols found in green tea. Vanillic acid and 4 hydroxy3methoxyphenylacetic acid result from the methylation of protocatechuic acid and 3, 4 dihydroxyphenylacetic acid, respectively. Protocatechuic acid is a catabolite of epinephrine.
1290 561 682 1341 1 559 882 1400 289 464 815 1305 538 1199 1176 62 1487 1213 614 451 1325 441 1123 230 101 398 802 309 608 1235 1094 936 1200 275